Brief Description of Tumblr.
ennephellemnen:

I /was/ going to do the maladaptive thing and not reblog it, but I thought, “fuck it, let’s not”.

ennephellemnen:

I /was/ going to do the maladaptive thing and not reblog it, but I thought, “fuck it, let’s not”.

neuromorphogenesis:

To quash depression, some brain cells must push through the stress
The nature of psychological resilience has, in recent years, been a subject of enormous interest to researchers, who have wondered how some people endure and even thrive under a certain amount of stress, and others crumble and fall prey to depression. The resulting research has underscored the importance of feeling socially connected and the value of psychotherapy to identify and exercise patterns of thought that protect against hopelessness and defeat.
But what does psychological resilience look like inside our brains, at the cellular level? Such knowledge might help bolster peoples’ immunity to depression and even treat people under chronic stress. And a new study published Thursday in Science magazine has made some progress in the effort to see the brain struggling with — and ultimately triumphing over — stress.
A group of neuroscientists at Mount Sinai’s Icahn School of Medicine in New York focused on the dopaminergic cells in the brain’s ventral tegmentum, a key node in the brain’s reward circuitry and therefore an important place to look at how social triumph and defeat play out in the brain. In mice under stress because they were either chronically isolated or rebuffed or attacked by fellow littermates, the group had observed that this group of neurons become overactive.
It would logically follow, then, that if you don’t want stressed mice (or people) to become depressed, you would want to avoid hyperactivity in that key group of neurons, right?
Actually, wrong, the researchers found. In a series of experiments, they saw that the mice who were least prone to behave in socially defeated ways when under stress were actually the ones whose dopaminergic cells in the ventral tegmental area displayed the greatest levels of hyperactivity in response to stress. And that hyperactivity was most pronounced in the neurons that extended from the tegmentum into the nearby nucleus accumbens, also a key node in the brain’s reward system.
The researchers wondered whether inducing similar hyperactivity in mice prone to depression — effectively pushing these cells to signal even faster and harder — might help bolster them against succumbing to passivity and defeat when under stress? Using antidepressant medication, viruses and lights that turn circuits on and off, they found that it could. By activating the chemical processes that induced the same level of hyperactivity seen in the ventral tegmenta of resilient mice, they made depression-prone mice more hardy and happy in the face of stress.
The results suggest something profound about the brain and depression: that in the healthy and psychologically resilient, stress induces its own chemical countermeasures, fostering a sort of psychological equilibrium. Someday medications might employ strategies that help promote such equilibrium to head off depression before it starts, as well as to treat it once it has set in.

neuromorphogenesis:

To quash depression, some brain cells must push through the stress

The nature of psychological resilience has, in recent years, been a subject of enormous interest to researchers, who have wondered how some people endure and even thrive under a certain amount of stress, and others crumble and fall prey to depression. The resulting research has underscored the importance of feeling socially connected and the value of psychotherapy to identify and exercise patterns of thought that protect against hopelessness and defeat.

But what does psychological resilience look like inside our brains, at the cellular level? Such knowledge might help bolster peoples’ immunity to depression and even treat people under chronic stress. And a new study published Thursday in Science magazine has made some progress in the effort to see the brain struggling with — and ultimately triumphing over — stress.

A group of neuroscientists at Mount Sinai’s Icahn School of Medicine in New York focused on the dopaminergic cells in the brain’s ventral tegmentum, a key node in the brain’s reward circuitry and therefore an important place to look at how social triumph and defeat play out in the brain. In mice under stress because they were either chronically isolated or rebuffed or attacked by fellow littermates, the group had observed that this group of neurons become overactive.

It would logically follow, then, that if you don’t want stressed mice (or people) to become depressed, you would want to avoid hyperactivity in that key group of neurons, right?

Actually, wrong, the researchers found. In a series of experiments, they saw that the mice who were least prone to behave in socially defeated ways when under stress were actually the ones whose dopaminergic cells in the ventral tegmental area displayed the greatest levels of hyperactivity in response to stress. And that hyperactivity was most pronounced in the neurons that extended from the tegmentum into the nearby nucleus accumbens, also a key node in the brain’s reward system.

The researchers wondered whether inducing similar hyperactivity in mice prone to depression — effectively pushing these cells to signal even faster and harder — might help bolster them against succumbing to passivity and defeat when under stress? Using antidepressant medication, viruses and lights that turn circuits on and off, they found that it could. By activating the chemical processes that induced the same level of hyperactivity seen in the ventral tegmenta of resilient mice, they made depression-prone mice more hardy and happy in the face of stress.

The results suggest something profound about the brain and depression: that in the healthy and psychologically resilient, stress induces its own chemical countermeasures, fostering a sort of psychological equilibrium. Someday medications might employ strategies that help promote such equilibrium to head off depression before it starts, as well as to treat it once it has set in.

ennephellemnen:

thegirlwiththeloontattoo:

People say “phase” like impermanence means insignificance. Show me a permanent state of the self.

but also things about theory of mind. The dismissal of whatever you’re doing being “just a phase” is for the comfort of others around you, who…

I’m too tired and derpy to play StarCraft properly so I started taking dramatic selfies instead.

I’m too tired and derpy to play StarCraft properly so I started taking dramatic selfies instead.

borrowedphrases:

the-megs:

guruthethird:

padalurki:

isaacedlahey:

on a scale of one to (500) days of summer how much do people completely misinterpret what you’re trying to say

romeo & juliet

Fight Club

The Great Gatsby

The Bible.

"It’s a metaphor"

scaels:

valeatrahslane:

290pika:

scaels:

Band snapchats are the best snapchats

Godzilla Eats Las Vegas is best band piece

Please tell me this isn’t the flute part

Its piccolo

Streetlight Manifesto, Linoleum - Album:99 songs of revolution 1,275

fronttbutts:

That’s me inside your head

morgulblade:
39. 
Me

Talk about things you wish you’d known earlier.

1. There’s nothing virtuous about self-loathing, and that there isn’t such a thing as virtue in the first place - there are only actions that validate your existence and actions that waste it. There’s only really pleasure, pain, and death - pleasure is more pleasurable the more you work for it (succeeding at a complex task > binge eating), but spare time for the easy stuff too or you’ll burn out; pain is inevitable but transient so don’t be so scared, (and for the love of god don’t inflict it on yourself because you feel like you ~deserve it, you’re wasting your goddamn time); death is just the end of both things, and the only real “rock bottom” (if you’re still alive, you can still change yourself). 

 2. You can use this thing called logic to make calls on whether things are real or not. Something is true when it works, something is not true when it stops working. Just because someone is yelling something at you doesn’t mean it’s true; just because someone is more powerful and confident than you doesn’t mean that they’re right.

3. The less you involve your ego in something, the more you’ll get of it. You can spend your life building whole monuments to your ego, but you’ll feel really cheap when you realize that they don’t matter that much to you, because you’re still unfulfilled. Don’t use love or success as reassurance that you are worthy, enjoy these things in and of themselves. You are tiny. You are a really complicated TV aerial that picks up raw data signals and then makes pictures and sounds out of them. Enjoy that process.

4. Give love. Don’t worry so much about getting love, it will come to you if you make yourself open to it. Pity isn’t love. Praise isn’t love, although it can come with it. Trying to manipulate these things out of people isn’t going to keep you satisfied for very long, and it will ultimately put even more distance between yourself and them, leaving you even more lonely. People generally won’t resent you for reaching out to them, people will resent you for using them as a one-sided repository for your emotional needs. There’s a difference.

5. Don’t wait around for someone to define sexual experience for you. You are the subject, not the object.

omfgcate:

dqdbpb:

we’re halfway thru april, u know what tht means?

image

#ITS GONNA BE MAY